Upregulated PRSS22 predicts lymph node metastasis and poor prognosis,and promotes cell invasiveness in breast cancer
10.3969/j.issn.1009-9905.2024.02.005
- VernacularTitle:乳腺癌中PRSS22表达与淋巴结转移及预后的关系
- Author:
Zhao-Xin GAO
1
;
Ya-Wen WANG
;
Xu CHEN
Author Information
1. 山东大学 第一临床学院(山东大学齐鲁医院)(山东 济南 250012)
- Keywords:
Breast neoplasms;
PRSS22;
Lymph node metastasis;
Prognosis;
Migration and in-vasion
- From:
Chinese Journal of Current Advances in General Surgery
2024;27(2):111-116
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of PRSS22 in breast cancer and its rela-tionship with clinicopathological parameters and patients'prognosis.Methods:Fifty-six cases of fresh breast cancer tissues and 10 paracancerous breast tissues were collected from Qilu Hospital of Shandong University.Real-time quantitative PCR was used to detect the expression of PRSS22.Its relationship with clinical pathological parameters was analyzed.Bioinformatics websites were used to analyze the expression and prognostic values of PRSS22.Migration and invasion assays were used to explore the effect of PRSS22 on the migration and invasion.Results:Expression of PRSS22 was up-regulated in breast cancer tissues compared with paracancerous breast tissues.PRSS22 was higher in breast cancer tissues with lymph node metastasis than those without lymph node metastasis,and its expression was positively correlated with the number of lymph node metastasis.Patients with high expression of PRSS22 had a poorer prognosis.PRSS22 was an inde-pendent prognostic factor.PRSS22 promoted the migration and invasion ability of breast cancer cells.Conclusion:PRSS22 is elevated in breast cancer,and its high expression is associated with lymph node metastasis and poor prognosis.PRSS22 has the potential to become a potential biomarker and therapeutic target for breast cancer.
