Research advances in exosomes involved in the occurrence, development and clinical diagnosis and treatment of sepsis
10.3760/cma.j.cn121430-20230809-00601
- VernacularTitle:外泌体参与脓毒症发生发展及临床诊治方面的研究进展
- Author:
Yilin ZHAO
1
;
Tiantian LIU
;
Chunxia WANG
Author Information
1. 上海市儿童医院 上海交通大学医学院附属儿童医院重症医学科，上海 200062
- Keywords:
Sepsis;
Exosome;
Novel detection technology;
Pathological mechanism;
Clinical application
- From:
Chinese Critical Care Medicine
2024;36(2):221-224
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host immune response to infection. The development of sepsis is accompanied by the secretion of exosomes by a variety of cells, including non-coding RNA, metabolic small molecules and proteins, which play an important role in immune inflammatory response, oxidative stress, and coagulation dysfunction. The rapid development of new detection technologies has promoted the application of exosomes in the early warning, severity stratification, treatment effect and prognosis evaluation of sepsis. This article reviews the new detection technology of exosomes, the involvement of exosomes in the pathological progress of sepsis, and the latest progress in the early diagnosis, disease assessment and treatment of sepsis, in order to provide new ideas for the diagnosis and treatment of sepsis.
