Research progress on dynamic modification and regulation of m6A methylation in insulin resistance

VernacularTitle:m6A甲基化对胰岛素抵抗动态修饰及调控的研究进展
Author: Cai JIANG ¹ ; Yue HU ; Cong CHEN
Author Information

1. 350122 福州,福建中医药大学康复医学院
Keywords: Insulin resistance; N6-methyladenosine; Insulin target organ; Regulation
From: Chinese Journal of Diabetes 2024;32(3):218-221
CountryChina
Language:Chinese
Abstract: Insulin resistance(IR)is an abnormal pathological and physiological process characterized by a decrease in the ability of target tissues and organs to utilize insulin.There are many factors related to IR.Epigenetic modification is one of the important regulatory mechanisms that cause IR.N6-methyladenosine(m6A)is an epigenetic modification with high abundance in Eukaryote mRNA.Its dynamic changes can regulate the expression of related enzymes,affect IR process and exert different biological effects in target organs.This article reviews the research progress of dynamic modification and regulation of m6A methylation in IR.