The multiple pharmacological effects of Sangzhi alkaloids based on different pathogenesis of diabetes mellitus
10.3969/j.issn.1006-6187.2024.02.014
- VernacularTitle:从糖尿病的发病机制看中药桑枝总生物碱的多重药理作用
- Author:
Xiaoling CAI
1
Author Information
1. 100044 北京大学人民医院内分泌代谢科
- Keywords:
Diabetes mellitus;
Sangzhi alkaloids;
Pathogenesis
- From:
Chinese Journal of Diabetes
2024;32(2):155-159
- CountryChina
- Language:Chinese
-
Abstract:
Despite researches on the pathogenesis,prevention and treatment of type 2 diabetes mellitus(T2DM)are progressing,the prevalence and incidence of T2DM are still rising worldwide.Updatedly,with the improved understanding of the pathophysiological mechanisms of T2DM,drugs with multiple biological pathways to effectively control blood glucose,protect islet β cells,and reduce the risk of cardiovascular and renal complications are highly needed.Nature medicines derived from nature often have multiple pharmaco-logical effects and little side effects.Compared with those chemical synthesis drugs,they have more potential to develop with multiple mechanisms in the treatment of diabetes and to ensure the safety of treatment.However,the"effective component"natural drug Sangzhi alkaloids(SZ-A),isolated from the traditional Chinese medicine,has unique characteristics of multiple pharmacological effects and few side effects.In fact,SZ-A can accurately act on double saccharase targets,by inhibiting the activity of glycosidase,to slow down the digestion and absorption of glucose,and to control the postprandial blood glucose level.Moreover,risks of gastrointestinal side effects with SZ-A treatment are lower than other glycosidase inhibitor drugs.Based on several evidence,the aim of this study is to explain the synergistic mechanisms of different alkaloid components,to find the clinical benefit of SZ-A treatment,to explore the potential effects of SZ-A for the treatment of metabolic syndrome.
