Correlation analysis between gene polymorphism of TCF7L2 and type 2 diabetes mellitus in the Uygur and Han populations in Xinjiang
10.3969/j.issn.1006-6187.2024.01.002
- VernacularTitle:新疆维吾尔族及汉族2型糖尿病患者TCF7L2基因多态性的研究
- Author:
Liming DONG
1
;
Yinhui LI
;
Hui LI
;
Hao LIU
Author Information
1. 830000 乌鲁木齐,新疆医科大学第一附属医院临床营养科
- Keywords:
Diabetes mellitus,type 2;
TCF7L2;
Gene polymorphism
- From:
Chinese Journal of Diabetes
2024;32(1):2-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the gene polymorphisms of rs7100927,rs10885409,rs4918789,rs290487 of TCF7L2 gene and type 2 diabetes mellitus(T2DM)of Uygur nationality and Han nationality.Methods 577 T2DM patients(T2DM group,293 Han and 284 Uyghu)were enrolled in the Department of Endocrinology,Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University from December 2013 to August 2015.In the same period,307 healthy subjects were selected as normal control(NC)group,of which 208 were Han Chinese and 99 were Uyghu.The polymorphism of TCF7L2 gene rs7100927,rs10885409,rs4918789 and rs290487 were identified by imLDRTM multiple SNP typing technique.Results In Uygur,the frequency of allele G at rs7100927 and rs4918789 of TCF7L2 gene and the frequency of allele C at rs10885409 and rs290487 in T2DM group were lower than those in NC group(P<0.05).Conclusion The G allele at rs7100927 and rs4918789 and C allele at rs10885409 and rs290487 of TCF7L2 gene may be protective factors for T2DM in Xinjiang Uygur population.
