Advances in the application of laser speckle contrast imaging in animal models of chronic cerebral hypoperfusion
10.3969/j.issn.1671-7856.2024.02.019
- VernacularTitle:激光散斑衬比成像技术在慢性脑缺血动物模型中的应用研究进展
- Author:
Xin TANG
1
;
Jie TAN
Author Information
1. 湖南中医药大学针灸推拿与康复学院,长沙 410208
- Keywords:
laser speckle contrast imaging;
chronic cerebral hypoperfusion;
animal model;
review
- From:
Chinese Journal of Comparative Medicine
2024;34(2):154-160
- CountryChina
- Language:Chinese
-
Abstract:
A visual and quantitative method of dynamically measuring microcirculatory blood flow in a tissue or organ in real time was developed using laser speckle contrast imaging technology.It has been used in numerous microcirculation detection domains because of its benefits of in vivo detection,real-time imaging,and ease of operation.Most animal models of chronic cerebral hypoperfusion involve decreasing blood flow to the brain from bilateral common carotid arteries,which can lead to a protracted deficit in cerebral blood supply.By monitoring and analyzing cortical cerebral blood flow,collateral circulation opening,and neurovascular coupling responses,laser speckle contrast imaging technology assesses the efficacy of modeling and the therapeutic effect of interventions in animal models of chronic cerebral hypoperfusion.This article summarizes the benefits and drawbacks of laser speckle contrast imaging in an animal model of chronic cerebral hypoperfusion to promote novel approaches to clinical care and academic study.
