Research progress on the role of autophagy in the pathogenesis of systemic sclerosis
10.3969/j.issn.1671-7856.2023.12.015
- VernacularTitle:自噬在系统性硬化症发病机制中作用的研究进展
- Author:
Xin LI
1
;
Xiaolin SUN
;
Yongfu WANG
Author Information
1. 内蒙古科技大学包头医学院,内蒙古 包头 014010
- Keywords:
autophagy;
systemic sclerosis;
angiopathy;
fibrosis;
signaling pathway
- From:
Chinese Journal of Comparative Medicine
2023;33(12):97-103
- CountryChina
- Language:Chinese
-
Abstract:
Systemic sclerosis(SSc)is an autoimmune disease characterized by vascular lesions and skin fibrosis,which causes structural and functional damage to multiple organs.The pathogenesis of SSc is complex and may be related to genetic and environmental factors as well as abnormal immune mechanisms.Autophagy is an evolutionarily conserved process of self-degradation in the body and participates in the pathogenesis of autoimmune diseases through various pathways.This article reviews the research progress on the role of autophagy in the angiopathy and fibrosis of SSc by regulating immune cells and mediating signaling pathways.
