Drug resistance and genetic diversity of clinical strains of Helicobacter pylori in the Qiannan Prefecture and Guiyang City,and their relationships with diseases
10.3969/j.issn.1002-2694.2024.00.007
- VernacularTitle:黔南州和贵阳市幽门螺杆菌临床菌株的耐药性、基因多样性及其与疾病的关系
- Author:
Yuan-Yuan ZHANG
1
;
Ke PAN
;
Meng-Heng MI
;
Yu-Zhu GUAN
;
Qiu-Dan LU
;
Juan ZHENG
;
Jin ZHANG
;
Tian-Shu WANG
;
Qi LIU
;
Zheng-Hong CHEN
Author Information
1. 贵州医科大学附属医院消化内科,贵阳 550004;贵州医科大学基础医学院微生物教研室/贵州省普通高校病原生物学特色重点实验室,贵阳 561113;黔南州人民医院,黔南 558000
- Keywords:
Helicobacter pylori;
Qiannan Prefecture;
Guiy-ang City;
gene polymorphism;
mixed infections
- From:
Chinese Journal of Zoonoses
2024;40(1):46-55
- CountryChina
- Language:Chinese
-
Abstract:
To understand Helicobacter pylori's drug resistance,genetic diversity,and relationship with clinical diseases in the Guiyang and Qiannan minority areas of Guizhou Province,we collected samples through endoscopy,and isolated and cul-tured H.pylori.The drug resistance and genotype characteristics were determined.The differences in different regions and dis-ease types were compared,and the structural characteristics of H.pylori and mixed infections with different strains of H.py-lori in Qiannan Prefecture were analyzed.A difference in the composition ratio of EPYIA typing in the cagA variable region was observed between the two areas(P=0.012),and the composition ratio of the vacA genotype differed(P=0.000).A total of 94.6％(53/56)new sequences of H.pylori strains from two regions were obtained by MLST.The rate of infection by H.pylori mixed with different strains was 44.4％in Qiannan Pre-fecture,and no significant difference was observed in the com-position of H.pylori mixed infections among patients with dif-ferent clinical diseases(P=0.349).Differences in EPI YA typ-ing and the vacA genotype composition ratio in the cagA varia-ble region of H.pylori were observed between the Qiannan Prefecture and Guiyang City.
