Inhibitory effects of Galidesivir(BCX4430)on rabies virus in vitro
10.3969/j.issn.1002-2694.2023.00.149
- VernacularTitle:加利地韦对狂犬病病毒体外抑制作用研究
- Author:
Yuan XIE
1
;
Ying-Lin CHI
;
Xiao-Yan TAO
;
Peng-Cheng YU
;
Qian LIU
;
Shu-Qing LIU
;
Wu-Yang ZHU
Author Information
1. 中国疾病预防控制中心病毒病预防控制所,卫健委生物安全重点实验室,北京 102206
- Keywords:
Galidesivir(BCX4430);
rabies virus;
inhibitory effects in vitro
- From:
Chinese Journal of Zoonoses
2023;39(12):1151-1157,1195
- CountryChina
- Language:Chinese
-
Abstract:
This study analyzed the inhibitory effects of BCX4430 on rabies virus with different virulence(CVS-11 and SC16)in vitro.Direct immunofluorescence(DFA),quantitative real-time PCR and half tissue culture infective dose(TCID50)assays were used.BCX4430(250 pmol/L),compared with T-705,significantly decreased the viral titer and the relative expres-sion level of viral mRNA,similarly to the inhibitory effects of ribavirin.Thus,our study demonstrated that BCX4430 signifi-cantly inhibits the replication of rabies virus in vitro.
