Progress on mechanism of type Ⅱ immune cells(Th2/ILC2)in allergic pulmonary inflammation
10.3969/j.issn.1000-484X.2024.01.002
- VernacularTitle:二型免疫细胞(Th2/ILC2)在肺部过敏性炎症中作用机制的研究进展
- Author:
Yaguang ZHANG
1
;
Bing SUN
Author Information
1. 西安交通大学第一附属医院Med-X研究院免疫代谢性疾病研究所,西安 710049
- Keywords:
Th2;
ILC2;
Allergic pulmonary inflammation
- From:
Chinese Journal of Immunology
2024;40(1):11-20
- CountryChina
- Language:Chinese
-
Abstract:
The type Ⅱ inflammatory response is primarily mediated by type 2 immune cells and cytokines,such as helper 2 cells(Th2)and group 2 innate lymphoid cells(ILC2),along with IL-4,IL-5 and IL-13.This response plays crucial roles in humoral immunity,parasite defense,toxin neutralization,tissue damage repair and regeneration.However,type-Ⅱ immune response can also contribute to the development of diseases.Currently,type Ⅱ inflammation is recognized to have physiological and pathological impli-cations in the skin,respiratory tract,digestive tract and adipose tissues.Moreover,it serves as a major cause of allergic diseases.Due to its unique immune microenvironment,the respiratory tract exhibits a high prevalence of type Ⅱ inflammation encompassing chronic sinusitis,allergic rhinitis,allergic asthma,allergic bronchopulmonary aspergillosis,and chronic obstructive pulmonary disease with eosinophilia among others.This review will focus on the research progress concerning Th2 and ILC2 cells in allergic pulmonary inflam-mation as well as targeted therapy for allergic diseases.
