Stains:recent research progress for endometriosis
10.12092/j.issn.1009-2501.2024.05.002
- VernacularTitle:他汀类药物治疗子宫内膜异位症的研究进展
- Author:
Xian QIN
1
;
Qian WANG
;
Jia HOU
;
Dongmei XU
Author Information
1. 重庆市妇幼保健院(重庆医科大学附属妇女儿童医院)妇产科,重庆 401120
- Keywords:
endometriosis;
statins;
lipid metabo-lism;
treatment
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(5):488-494
- CountryChina
- Language:Chinese
-
Abstract:
Defined as a common gynecologic en-docrine disease,endometriosis is characterized by the presence of endometrium outside of the uterus cavity,affecting about 10%to 15%of reproductive-aged women worldwide.Moreover,Asian women tend to have a nine-fold increased risk of endome-triosis compared with their white counterparts in Europe and the United States.Endometriosis not only causes chronic pelvic pain,dysmenorrhea,painful sex and other pain symptoms,but also leads to infertility,pushing the patients into a state of fatigue,high sensitivity and anxiety,thus reduc-ing their quality of life.As the aging of Chinese pop-ulation intensifies and the women's childbearing age delays,it is highly urgent to find solutions to those gynecological endocrine diseases such as en-dometriosis,which hamper women's fertility.In re-cent years,studies have shown that patients with endometriosis have abnormal serum lipid metabo-lism and an increased risk of cardiovascular diseas-es.At the same time,as a type of cholesterol-lower-ing drug,statins can inhibit the progression of en-dometriosis at the cellular and animal levels.Also,a few clinical studies have exhibited that statins ex-ert a positive effect on the treatment of endometri-osis.Therefore,this article aims to review the re-searches regarding the relationship between endo-metriosis and the cardiovascular disease,as well as the research progress of statin therapy on endome-triosis based on the level of cells,animals and hu-man beings.
