Effect of cervical Luschka joint degenerative change on expression of VEGF and its receptor
- VernacularTitle:颈椎钩椎关节退行性变对VEGF及其受体表达的影响
- Author:
Jie CHEN
1
;
Kun LI
;
Shao-Jie ZHANG
;
Xiao-He LI
;
Shang GAO
;
Hai-Yan WANG
;
Zhi-Jun LI
;
Yuan MA
;
Dan-Yang ZHAO
;
Jun SHI
;
Xing WANG
Author Information
- Keywords: cervical vertebra; Luschka joint; degenerative change; VEGF; VEGFR-2
- From: Journal of Regional Anatomy and Operative Surgery 2023;32(12):1025-1028
- CountryChina
- Language:Chinese
- Abstract: Objective To observe the effect of cervical degenerative change on the expression of vascular endothelial growth factor(VEGF)and vascular endothelial growth factor receptor-2(VEGFR-2).Methods The C3 to C7 segments of bilateral healthy cervical vertebrae of adult cadavers were taken as the control group,and the C3 to C7 segments of bilateral degenerative cervical vertebrae of adult cadavers were taken as the experimental group.The expression changes of VEGF and VEGFR-2 of the two groups were observed and analyzed by immunohistochemistry,immunofluorescence staining and real-time quantitative PCR.Results The protein and mRNA expressions of VEGF and VEGFR-2 in the experimental group were higher than those in the control group,with statistically significant differences(P<0.05).Conclusion Cervical Luschka joint degenerative change significantly up-regulates the expression of VEGF and VEGFR-2,which is closely related to the microenvironmental changes around the Luschka joint caused by degeneration of joint-like structure.
