Predictive efficacy of ultrasound-guided fine-needle aspiration combined with BRAF gene mutation detection for thyroid isthmus nodules
10.3760/cma.j.cn341190-20230330-00240
- VernacularTitle:超声引导下细针穿刺联合BRAF基因检测对甲状腺峡部结节预测效能的研究
- Author:
Xin YUE
1
;
Mingru YANG
;
Shang WANG
Author Information
1. 焦作市人民医院超声科，焦作 454000
- Keywords:
Thyroid nodule;
Biopsy,needle;
Ultrasonography;
Diagnosis;
ROC curve;
Area under curve
- From:
Chinese Journal of Primary Medicine and Pharmacy
2024;31(4):560-564
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the diagnostic utility of ultrasound-guided fine-needle aspiration (FNA) combined with BRAF V600E gene mutation detection for discerning benign from malignant thyroid isthmus nodules classified as thyroid imaging report and data system (TI-RADS) 4a and 4b. Methods:A retrospective analysis was conducted on the clinical data of 48 patients with thyroid nodules of TI-RADS 4, who underwent surgical confirmation and pathological diagnosis at Jiaozuo People's Hospital between October 2019 and June 2022. Using surgical and pathological outcomes as the gold standard, the diagnostic efficacy of FNA cytopathology, BRAF V600E gene mutation detection, and the combined approach were individually evaluated for benign and malignant thyroid nodules of TI-RADS 4. Results:The receiver operating characteristic curve analysis revealed the diagnostic values of FNA, BRAF V600E gene mutation detection, and their combined use in predicting the benignancy or malignancy of thyroid isthmus nodules. For TI-RADS 4a nodules, the areas under the curves were 0.876 for FNA, 0.852 for BRAF V600E gene mutation detection, and 0.952 for the combined approach. For TI-RADS 4b nodules, the areas under the curves were 0.850, 0.858, and 0.908, respectively. The P-values were 0.010, 0.016, and 0.002 for TI-RADS 4a nodules, and 0.006, 0.005, and 0.001 for TI-RADS 4b nodules. Notably, the combined approach demonstrated larger areas under the curves compared with individual applications. Conclusion:The combined use of FNA and BRAF V600E gene mutation detection enhances the diagnostic accuracy for thyroid isthmus nodules classified as TI-RADS 4a and 4b, as reflected by an increased area under the receiver operating characteristic curve.
