The value of serum amyloid protein A in the early diagnosis of neonatal sepsis and necrotizing enterocolitis
10.12138/j.issn.1671-9638.20243088
- VernacularTitle:血清淀粉样蛋白A在新生儿败血症、坏死性小肠结肠炎早期诊断中的价值
- Author:
Si-Jie SONG
1
;
Xiao-Yun ZHONG
Author Information
1. 重庆医科大学附属妇女儿童医院儿科,重庆 401147;重庆市妇幼保健院新生儿科,重庆 401147;重庆市妇幼保健院围产医学中心,重庆 401147
- Keywords:
serum amyloid protein A;
sepsis;
necrotizing enterocolitis;
neonate;
early diagnosis
- From:
Chinese Journal of Infection Control
2024;23(3):385-390
- CountryChina
- Language:Chinese
-
Abstract:
Early/late onset sepsis(EOS/LOS)and necrotizing enterocolitis(NEC)are common diseases during the neonatal period,with poor prognosis in severe cases.The early clinical manifestations are not specific,the diag-nosis is difficult,currently-used non-specific laboratory tests(C-reactive protein,procalcitonin,etc.)have disad-vantages,which may lead to missed diagnosis or misdiagnosis.Serum amyloid A(SAA)is a novel acute phase re-actant that increases significantly in the early stage of EOS/LOS and NEC,and lasts for a long time,it is related to the severity of the disease and can reflect the therapeutic effect,thus it can be used as a biomarker for diagnosis and treatment of these two diseases.This paper reviews SA A and its value in the early diagnosis of EOS/LOS and NEC,providing new references for the diagnosis and treatment of such diseases.
