Progress in role of silent information regulator 3 in improving idiopathic pulmonary fibrosis by regulating mitochondrial dysfunction
10.3969/j.issn.1000-4718.2024.02.020
- VernacularTitle:沉默信息调节因子3通过调节线粒体功能障碍减轻特发性肺纤维化的研究进展
- Author:
Shusen YANG
1
;
Yushan LIU
;
Yilin ZHANG
;
Yi HUI
;
Jingtao LI
;
Shuguang YAN
Author Information
1. 陕西中医药大学基础医学院,陕西 咸阳 712046
- Keywords:
idiopathic pulmonary fibrosis;
mitochondrial dysfunction;
silent information regulator 3;
DNA damage;
lipid metabolism
- From:
Chinese Journal of Pathophysiology
2024;40(2):358-364
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic pulmonary fibrosis(IPF)is a chronic progressive interstitial lung disease of unknown etiology,with a rapid disease course,poor prognosis,and the absence of effective therapeutic drugs.Mitochondrial dys-function is one of the crucial causes of inducing IPF.Silent information regulator 3(SIRT3)can restore mitochondrial ho-meostasis by inhibiting mitochondrial oxidative stress,repairing mitochondrial DNA damage,and ameliorating abnormal mitochondrial lipid metabolism.This paper summarizes the role and mechanism of SIRT3 in attenuating mitochondrial dys-function based on delineating the relationship between mitochondrial dysfunction and IPF,aiming to provide references for finding effective treatment methods for IPF.
