Progress in multicellular signal network and drug carriers based on exo-somes in regulation of cerebral ischemia-reperfusion injury

VernacularTitle:基于外泌体的多细胞信号网络和药物载体在调控脑缺血再灌注损伤中的研究进展
Author: Yu ZHOU ¹ ; Yong MA ; Bin LI ; Erqing CHAI
Author Information

1. 兰州大学第一临床医学院 ,甘肃兰州 730000;甘肃省人民医院脑血管病中心,甘肃省脑血管病重点实验室,甘肃兰州 730000
Keywords: cerebral ischemia-reperfusion injury; exsomes; drug carrier; stroke; cellular signaling network
From: Chinese Journal of Pathophysiology 2023;39(12):2280-2287
CountryChina
Language:Chinese
Abstract: Cerebral stroke has one of the highest incidence,mortality and disability rates worldwide.Al-though studies have confirmed that reperfusion therapy is an effective strategy for treating stroke patients,the secondary in-jury of brain tissue caused by reperfusion therapy,which is called cerebral ischaemia reperfusion injury(CIRI),is anoth-er medical challenge globally.The microenvironment network constructed by multicellular exosomes plays a regulatory role in the occurrence and development of CIRI.In addition,exosomes have potential value as drug delivery carriers for cerebrovascular diseases due to their stability,the ability to pass through the blood?brain barrier and other characteristics.This study reviews the research progress on the signal network constructed by multiple cells through exosomes and exo-somes as drug carriers in CIRI to provide a reference for research to improve CIRI.