Research Progress on Factors Affecting the Blood Concentration of Hydroxychloroquine
10.3870/j.issn.1004-0781.2024.02.011
- VernacularTitle:羟氯喹血药浓度影响因素的研究进展
- Author:
Xuan HUANG
1
;
Han XIE
;
Weihong GE
;
Yujie ZHOU
Author Information
1. 中国药科大学南京鼓楼医院药学部,南京 210008;中国药科大学基础医学与临床药学学院,南京 210009
- Keywords:
Hydroxychloroquine;
Blood drug concentration;
Influence factor
- From:
Herald of Medicine
2024;43(2):215-220
- CountryChina
- Language:Chinese
-
Abstract:
Originally used as an antimalarial drug,hydroxychloroquine is now widely used in the treatment of rheumatic immune diseases due to its cost-effectiveness,safety,and efficacy.In addition to its immunomodulatory effects,hydroxychloroquine also exhibits anti thrombotic,anti-hypolipidemic,and anti-hypoglycemic properties.Hydroxychloroquine blood levels are correlated with clinical outcomes and adverse reactions,and can reflect patient compliance.However,due to the complex pharmacokinetic profile of hydroxychloroquine,significant inter-individual differences in blood concentration exist even with the administration of the same dosage.This study investigates the factors affecting the blood concentration of hydroxychloroquine in terms of physiological factors,pathological factors,metabolic enzyme gene polymorphisms,and drug-related factors.The aim is to provide a reference for rational clinical use and the development of individualized dosing.
