Optimization of Extraction Process Parameters of Xiaohua Funing Tang by Chromatographic Fingerprint Similarity Index Combined with Response Surface Methodology
10.3870/j.issn.1004-0781.2023.12.012
- VernacularTitle:色谱指纹图谱相似指数结合响应面法优化消化复宁汤提取工艺参数
- Author:
Li CHEN
1
;
Sheng WANG
;
Di ZHANG
;
Rui CHENG
;
Yongzhong WANG
Author Information
1. 安徽中医药大学第一附属医院药学部/国家中医药管理局中药制剂三级实验室,合肥 230031
- Keywords:
Xiaohua Funing Tang;
Extraction process;
Central combined response surface;
Fingerprint;
Similarity index C;
Similarity index A
- From:
Herald of Medicine
2023;42(12):1813-1818
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the extraction process parameters of digestive Funing decoction.Methods Taking fingerprint similarity index(C,A),the total content of multiple components and extract yield as indexes,the extraction process parameters of Xiaohua Funing Tang were optimized by central composite design response surface methodology(RSCCD).Results The extraction times had a significant effect on the comprehensive score.The optimum extraction parameters were adding 9 times of water,decocting for 1.5 hour and extracting for 3 times.Under this condition,the predicted value of the comprehensive score was 100.333,and the verified mean value was 96.75,which was not significantly different from the predicted value.Conclusion The extraction process of Xiaohua Funing Tang determined in this paper is scientific,reasonable,stable and feasible.It lays a foundation for the research and development of later preparations.
