Effect of Common Carotid Artery Sympathectomy on Clinical Efficacy and Serum Levels of IL-6,IL-10 and TNF-α in Patients with Mixed Cerebral Palsy
10.11969/j.issn.1673-548X.2024.02.013
- VernacularTitle:颈总动脉交感神经网剥脱术对混合型脑性瘫痪临床疗效及血清IL-6、IL-10、TNF-α水平的影响
- Author:
Yawei FU
1
;
Chunyu ZHANG
;
Jiang SHAO
Author Information
1. 830000 乌鲁木齐,新疆医科大学第二附属医院神经外科
- Keywords:
Cerebral palsy;
Common carotid artery;
Sympathectomy;
Inflammatory factor;
Therapeutic effect
- From:
Journal of Medical Research
2024;53(2):62-66
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of common carotid artery sympathectomy on clinical efficacy and serum inflammatory factors in children with mixed cerebral palsy.Methods Common carotid artery sympathectomy was performed in 50 children with mixed cerebral palsy.The levels of IL-6,IL-10,TNF-α,modified Ashworth spasm score,teacher drooling scale(TDS)grade and gross motor function classification system(GMFCS)were compared before and after operation.Results The levels of IL-6 and TNF-α in 50 children with mixed cerebral palsy after operation were significantly lower than those before operation,and the difference was statistical-ly significant(P＜0.05);but there was no significant difference in the level of IL-10 after operation.The modified Ashworth spasm score and TDS grade after operation were significantly better than those before operation,and the differences were statistically significant(P＜0.05);but there was no significant difference in GMFCS after operation(P＞0.05).The level of TNF-α before and after opera-tion was positively correlated with modified Ashworth spasm score and TDS grade,but there was no correlation between TNF-α level and GMFCS before and after operation,and there was no correlation between IL-6,IL-10 level and modified Ashworth spasm score,TDS salivation grade and GMFCS before and after operation.Conclusion IL-6,IL-10 and TNF-α are involved in the pathogenesis of mixed cerebral palsy,and common carotid artery adventitia sympathectomy can improve clinical symptoms by reducing the levels of IL-6 and TNF-α,which is worth of popularization and application.
