Ocular Hemodynamic Characteristics before and after Treatment of Diabetic Retinopathy
10.11969/j.issn.1673-548X.2023.12.029
- VernacularTitle:糖尿病视网膜病变治疗前后眼部血流动力学特征
- Author:
Xinming PENG
1
;
Peng CHEN
;
Yiwen LIU
Author Information
1. 071000 保定,河北大学附属医院眼科
- Keywords:
Diabetic retinopathy;
Central retinal artery;
Hemodynamics
- From:
Journal of Medical Research
2023;52(12):145-149
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the ocular hemodynamic characteristics before and after treatment of diabetic retinopathy(DR).Methods This study was a case-control study using a non-random sampling method.A total of 86 DR patients(86 eyes)and 43 healthy subjects who were diagnosed and treated in the Affiliated Hospital of Hebei University from December 2021 to April 2022 were selected as the research objects.Among them,86 DR patients were set up as the observation group,and 43 healthy subjects were set up as the control group.The central retinal artery(CRA),peak systolic velocity(PSV),end-diastolic velocity(EDV),and resistance in-dex(RI)were compared between the two groups.And according to the results of fluorescein fundus angiography(FFA)and macular opti-cal coherence tomography(OCT),the observation group was divided into PRP group[treated with panretinal photocoagulation(PRP)]and VEGF group[treated with intravitreal injection of anti-vascular endothlial growth factor(VEGF)],43 cases in each group.The curative effect was observed,the changes of PSV,EDV and RI before and after surgery were compared,and the area under the curve(AUC),sensitivity and specificity of PSV,EDV and RI for predicting curative effect were analyzed by receiver operating characteristic(ROC)curve model.Results PSV and EDV in the observation group were lower than those in the control group,but RI was higher than that in the control group(P＜0.05).All patients in PRP group successfully completed PRP treatment,with a total effective rate of 88.37％;PSV and EDV at 1day and 1 week after operation were higher than those before operation,while RI was lower than before opera-tion(P＜0.05);There was no significant difference in PSV and EDV at 1week after operation compared with 1day after operation(P＞0.05),while RI was lower than that at 1day before operation(P＜0.05).All patients in VEGF group successfully completed intravitreal injection of anti-VEGF therapy,with a total effective rate of 86.04％;PSV and EDV at 1 day and 1 week after operation were higher than those before operation,while RI was lower than before operation(P＜0.05);PSV and EDV at 1 week were lower than those at 1day after operation,while the RI was higher than that at 1day before operation(P＜0.05).ROC curve analysis showed that the AUC values of PSV,EDV and RI for predicting the efficacy of PRP in the treatment of stage Ⅰ-Ⅲ DR were 0.879,0.831,0.894(P＜0.05),re-spectively;the AUC values of PSV,EDV and RI for predicting the efficacy of intravitreal injection of anti-VEGF in the treatment of stageⅣ DR were 0.860,0.881,0.831(P＜0.05).Conclusion Both PRP and intravitreal injection of anti-VEGF have good curative effects in the treatment of stage Ⅰ-Ⅳ DR,which can effectively increase the PSV and EDV of the CRA and reduce the RI.And color Doppler ultrasound was used to observe the changes of ocular hemodynamics in patients with DR before and after operation,which is bene-ficial to provide reference for clinical diagnosis and treatment.
