Meta-analysis of the Relationship between Blood Inflammatory Marker Levels and Attention Deficit Hyperactivity Disorder in Children
10.11969/j.issn.1673-548X.2023.11.015
- VernacularTitle:血液炎症标志物水平与儿童注意缺陷多动障碍关系的Meta分析
- Author:
Xuejun LI
1
;
Shumin WANG
;
Yixing ZHANG
Author Information
1. 200032 上海中医药大学附属龙华医院儿科
- Keywords:
Attention deficit hyperactivity disorder;
Blood inflammatory markers;
Meta-analysis;
Children
- From:
Journal of Medical Research
2023;52(11):74-83
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between the level of blood inflammatory markers and attention deficit hyperactivity disorder(ADHD)in children,and to provide evidence for early intervention and prevention of ADHD.Methods Relevant literatures published in PubMed,Embase,Web of Science,Cochrane Library,CNKI,Wanfang Data Knowledge Service Platform,VIP Chinese Journal Service Platform,and China Biomedical Literature Database were retrieved as of May 20,2022.Two investigators independently screened the literature and extracted information,and carried out quality evaluation.RevMan 5.3 and Stata 16.0software were used for Meta-analysis and publication bias testing.Results A total of 15 literatures were included,with a total sample size of 2199 cases.Me-ta-analysis results showed that:the serum interleukin-6(IL-6)level in ADHD group was significantly higher than that in healthy control group(SMD =0.98,95%CI:0.10-1.86,P =0.03);subgroup analysis found that the serum IL-6 level in the ADHD group in African countries was higher than that in the healthy control group(P<0.001);for studies with a total sample size of 60 cases,100-120 cases in the case and control groups,the serum IL-6 level in the ADHD group was higher than that in the healthy control group(P<0.001).There was no significant difference in serum IL-1β level between ADHD group and healthy control group(SMD =0.70,95%CI:-0.46-1.86,P =0.24).There was no significant difference in serum TNF-α level between ADHD group and healthy con-trol group(SMD =-0.26,95%CI:-1.29-0.77,P =0.62).The blood neutrophil-to-lymphocyte ratio(NLR)of ADHD group was significantly higher than that of healthy control group(SMD =0.63,95%CI:0.25-1.01,P =0.001),subgroup analysis found that the NLR value of ADHD group was higher than that of healthy control group in studies with a sample size of less than 100 cases(SMD =0.71,95%CI:0.47-0.96,P<0.001).Conclusion Serum IL-6 levels and NLR values were higher in children with ADHD than in healthy children,suggesting that blood inflammatory markers may play a key role in the etiological mechanism of ADHD and that anti-in-flammatory measures may have positive significance for the treatment and prevention of ADHD.
