Aging and age-related macular degeneration
10.3760/cma.j.cn115989-20200602-00392
- VernacularTitle:衰老与年龄相关性黄斑变性
- Author:
Yi LEI
1
;
Hua YAN
Author Information
1. 天津医科大学总医院眼科 天津医科大学，天津 300052
- Keywords:
Aging;
Age-related macular degeneration;
Bruch membrane;
Oxidative stress
- From:
Chinese Journal of Experimental Ophthalmology
2024;42(1):76-79
- CountryChina
- Language:Chinese
-
Abstract:
With the aging of the population in modern society, the incidence of age-related diseases increases gradually, especially the age-related macular degeneration (AMD). Despite advances in treatment in recent years, AMD remains one of the leading causes of blindness and visual impairment in the elderly.At present, people tend to think that AMD is caused by the combination of aging and inflammation, which also contribute to the occurrence and development of many other age-related diseases.Although more studies have focused on the role of inflammation in AMD, aging, as an important correlate, is also deserves in-depth investigation.This article reviewed the close relationship between substance accumulation, abnormal phagocytosis, abnormal mitochondrial function and oxidative stress damage caused by aging and the occurrence and development of AMD, with a view to improving clinicians' knowledge of AMD.
