Research progress on the inhibition of photoreceptor cell apoptosis by the pentose phosphate pathway and its molecular mechanism
10.3760/cma.j.cn115989-20210317-00179
- VernacularTitle:磷酸戊糖途径抑制感光细胞凋亡及分子机制的研究进展
- Author:
Siyang HAN
1
;
Xiaodong SUN
Author Information
1. 上海交通大学附属第一人民医院眼科 国家眼部疾病临床医学研究中心 上海市眼部疾病临床医学研究中心 上海市眼底病重点实验室 上海眼视觉与光医学工程技术研究中心 上海市眼科疾病精准诊疗工程技术研究中心，上海 200080
- Keywords:
Photoreceptor cells;
Apoptosis;
Pentose phosphate pathway;
Oxidative stress;
Lipid metabolism;
Review
- From:
Chinese Journal of Experimental Ophthalmology
2024;42(1):72-75
- CountryChina
- Language:Chinese
-
Abstract:
Photoreceptor cells are a special type of neuroepithelial cells, which play an important role in the generation and transmission of visual signals.They mainly meet the physiological needs by ingesting a large amount of glucose for glucose metabolism.Photoreceptor cell apoptosis is a common cause of blindness in patients with retinal diseases, which is accompanied by changes in oxidative stress and anabolism.Recent studies have found that pentose phosphate pathway, an important branch of glucose metabolism, plays an essential role in the development of the above-mentioned pathology.Its product, nicotinamide adenine dinucleotide phosphate (NADPH), as a crucial hydrogen donor in photoreceptor cells, participates in substance synthesis and metabolism, resists oxidative stress, and then inhibits apoptosis of photoreceptor cells.This review summarized the mechanism of pentose phosphate pathway in inhibiting photoreceptor cell apoptosis from the perspective of view of metabolic activity and molecular pathway to provide reference for clinical scientific research.
