Research progress of microglia activation in the regulatory mechanism of ret-initis pigmentosa
10.13389/j.cnki.rao.2024.0031
- VernacularTitle:小胶质细胞活化在视网膜色素变性中的调控机制研究进展
- Author:
Wei ZHOU
1
;
Lina LIANG
Author Information
1. 100040 北京市,中国中医科学院眼科医院眼功能实验室
- Keywords:
microglia;
activation;
retinitis pigmentosa;
regulatory mechanism
- From:
Recent Advances in Ophthalmology
2024;44(2):159-163
- CountryChina
- Language:Chinese
-
Abstract:
Retinitis pigmentosa(RP)is a hereditary retinal degenerative ocular disease.Accumulating studies have demonstrated that microglia(MG)activation occurs at the early stage of retinal degeneration.MG,as immune cells in the central nervous system and retina,are involved in the formation of the front line of the innate immune system,exhibiting neuroprotective or neurotoxic effects in various neurodegenerative processes.The neurotoxic or neuroprotective effects re-sulting from microglia activation may influence the pathological progression of RP.Consequently,therapeutic strategies tar-geting MG,aiming to modulate disease progression and outcome by balancing neuroprotective or neurotoxic effects,repre-sent a promising avenue for future treatment.
