Research progress of role of mitochondrial dysfunction in diabetic cardiomyopathy
10.3969/j.issn.1008-0074.2024.01.20
- VernacularTitle:线粒体功能障碍在糖尿病心肌病中的作用研究进展
- Author:
Xiao-Ting HAN
1
;
Hai-Yan SONG
Author Information
1. 哈尔滨医科大学附属第二医院内分泌代谢病科,黑龙江 哈尔滨 150081
- Keywords:
Diabetic cardiomyopathies;
Mitochondria;
diabetes mellitus;
Fibrosis
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(1):94-97
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic cardiomyopathy(DCM)is a complication of diabetes mellitus.It is characterized by abnormal myocardial cells leading to diastolic and systolic dysfunction,which can eventually lead to heart failure,impair the health of diabetic patients and worsen the poor prognosis.Studies indicated that mitochondrion directly participated in occurrence and development of DCM,involving glucose and lipid metabolic regulation,calcium homeostasis main-tenance,reactive oxygen species(ROS)level and oxidative stress etc.,whose normal functioning is necessary for human health.Mitochondrial dysfunction is closely associated with occurrence and development of DCM.The pres-ent article makes a review on mitochondrial structure and physiological function,dynamics and dysfunction,and role of mitochondrial dysfunction in DCM,and explore new targets for the prevention and treatment of DCM.
