Augmented renal clearance in septic patients with antibiotic blood concentration
10.3760/cma.j.issn.1673-4912.2024.01.012
- VernacularTitle:脓毒症患者肾脏清除率增加与抗生素血药浓度
- Author:
Zixuan LI
1
;
Chunfeng LIU
Author Information
1. 中国医科大学附属盛京医院儿童急诊与重症医学科，沈阳 110004
- Keywords:
Augmented renal clearance;
Sepsis;
Antibiotics;
Pharmacokinetic;
Pharmacodynamic
- From:
Chinese Pediatric Emergency Medicine
2024;31(1):62-67
- CountryChina
- Language:Chinese
-
Abstract:
Augmented renal clearance（ARC）can be caused by the disease itself，inflammatory state，or therapeutic interventions，and is often associated with severe infections and trauma.Sepsis is one of the most important diseases with high morbidity and mortality in the world.Current studies suggest that ARC is significantly associated with inadequate antimicrobial therapy concentration in patients with sepsis，increasing the risk of clinical treatment failure.It is important to optimize the drug administration strategy for patients with ARC in sepsis，although the current clinical screening of ARC is not yet perfect.This review summarized the literature on changes in blood concentration of antibiotics and administration strategies in patients with sepsis with ARC，in order to provide appropriate medication and clinical guidance for ARC patients.
