Clinical characteristics of eosinophilic gastroenteritis in children under six years old
10.3760/cma.j.issn.1673-4912.2024.01.008
- VernacularTitle:六岁以下儿童嗜酸细胞性胃肠炎临床特征分析
- Author:
Jing LI
1
;
Jin ZHOU
;
Yan ZHAO
;
Jie WU
;
Tianyou WANG
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院消化科 100045
- Keywords:
Child,preschool;
Infant;
Eosinophilic gastrointestinal diseases;
Clinical characteristics
- From:
Chinese Pediatric Emergency Medicine
2024;31(1):41-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical characteristics of eosinophilic gastroenteritis in children under 6 years old.Methods:The clinical data，laboratory examinations，imaging examinations，gastrointestinal endoscopy，histopathology，treatment，and prognosis of patients under 6 years old with eosinophilic gastroenteritis who were hospitalized in the Department of Gastroenterology，Beijing Children's Hospital from January 1，2016 to December 31，2022 were collected and analyzed.Results:A total of 31 children under 6 years of age with eosinophilic gastroenteritis were enrolled in the study,including 14 cases≤3 years old and 17 cases>3 years old, and 38.71% (12/31) of them had multiple sites involved. The main clinical manifestations were abdominal pain（20/31，64.52%），vomiting（11/31，35.48%），hematochezia（7/31，22.58%），and diarrhea（7/31，22.58%）.The children with eosinophilic duodenitis and eosinophilic colitis were more likely to have abdominal pain, with an incidence of 83.33%(10/12)（ P<0.05）. Eosinophilia increased in 70.97%（22/31）of children，which was more common in children >3 years of age（88.24% vs. 50.00%， P<0.05）.Anemia was seen in 29.03%（9/31）of the patients，and it was more common in children under 3 years of age（50.00% vs. 11.76%， P<0.05）.Hypoalbuminemia was found in 22.58%（7/31）of patients. Specific IgE（sIgE）was positive in 73.33%（22/30）of children. Milk，egg，and wheat were the most common allergens. Gastrointestinal endoscopy showed mucosal edema（29/31，93.55%），erythema（26/31，83.87%），roughness（12/31，38.71%），ulcer（10/31，32.26%），et al.All children were treated with the elimination diet. Besides,10 cases were treated with omeprazole, 16 cases were treated with montelukast, and 17 cases were treated with glucocorticoid. The incidence of relapse or steroid resistance was 32.26%（10/31），and 70.00%（7/10）of them occurred within one year of treatment. Conclusion:Eosinophilic gastroenteritis in children under 6 years of age may involve single or multiple sites.Abdominal pain is the most common clinical manifestation. Children may have elevated peripheral blood eosinophils，anemia，or hypoalbuminemia.Most children have food allergens. Nearly one-third of children experience relapse or steroid resistance.
