Sepsis endotype-changes over time and space
10.3760/cma.j.issn.1673-4912.2024.01.002
- VernacularTitle:脓毒症内表型——随时间和空间变化
- Author:
Chunxia WANG
1
;
Yucai ZHANG
Author Information
1. 上海市儿童医院 上海交通大学医学院附属儿童医院重症医学科 200026
- Keywords:
Sepsis;
Heterogeneity;
Endotype;
Multiomics
- From:
Chinese Pediatric Emergency Medicine
2024;31(1):8-13
- CountryChina
- Language:Chinese
-
Abstract:
The heterogeneity of sepsis plays critical roles in determining the response of clinical intervention and the outcome of sepsis.Based on the host-response revealed from multiomics,the new idea of the endotype of sepsis was revealed from multiple perspectives,such as transcriptome,proteome,epigenome,and exosome signature spectrum,etc.In recent years,in the field of sepsis endotype,the research of clinical subtype,metabolic subtype,and immune subtype is booming.This concept has gradually penetrated into multiple aspects,including the diagnosis,severity assessment,patients screening for clinical research,and the reference for individualized clinical treatment.It brings a new perspective for clinical individualized treatment of sepsis.
