Advantages,discomfort and challenges of clinical application of orthopedic hemostatic materials
- VernacularTitle:骨科止血材料临床应用的优势、不适与面临的挑战
- Author:
Chuang LIU
1
;
Shuo SHAN
;
Tengbo YU
;
Huan ZHOU
;
Lei YANG
Author Information
- Keywords: orthopedic hemostatic material; bone wax; hemostatic osteogenic integration; biomedical material; review
- From: Chinese Journal of Tissue Engineering Research 2024;28(5):795-803
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Bone wax is a filler that can be used for bone hemostasis.Although modification of bone wax formulations is attempted worldwide,its inertness is still the main challenge today.There is an urgent clinical need to develop novel orthopedic hemostatic materials with hemostasis,osteogenesis and antibacterial properties. OBJECTIVE:To review the development of orthopedic hemostatic materials including bone wax and its substitutes. METHODS:PubMed,Web of Science,WanFang,CNKI and VIP databases were searched for literature related to bone wax,hemostatic materials,and research progress of orthopedic hemostatic materials,and 136 articles were selected for inclusion in the review by reading the abstracts of the articles in the initial screening. RESULTS AND CONCLUSION:To replace traditional bone wax,researchers have developed various orthopedic hemostatic materials based on the needs of practical scenarios such as hemostasis and osteogenesis.However,relevant studies mostly focus on basic physical and chemical and performance tests,lack a systematic evaluation system,and lack sufficient reports of large animal experiments and clinical trials.Therefore,bone wax is still a recognized orthopedic hemostatic material at present.The fundamental reason is that the design of existing materials cannot timely meet the new needs of intraoperative hemostasis,postoperative osteogenesis and clinical practice.In the future,the structure,composition and function of existing hemostatic and osteogenic materials need to be integrated and redesigned to meet the increasing demand for hemostatic and osteogenic materials.
