Progress of Research on NAD+ Metabolic Pathway in Treatment of Inflammatory Bowel Disease
10.3969/j.issn.1008-7125.2023.12.009
- VernacularTitle:NAD+代谢途径在炎症性肠病治疗中的研究进展
- Author:
Longxiang ZHANG
1
;
Hongliang GAO
Author Information
1. 新疆医科大学第一附属医院消化病二科(830054)
- Keywords:
Nicotinamide Adenine Dinucleotide;
Antioxidation;
Inflammatory Bowel Disease;
Therapy
- From:
Chinese Journal of Gastroenterology
2023;28(12):757-762
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease(IBD),including ulcerative colitis(UC)and Crohn's disease(CD),is a systemic inflammatory disease.Nicotinamide adenine dinucleotide(NAD+)is widely used as a cofactor or substrate in biochemical reactions and is closely related to physical health.The close relationship between IBD and NAD+has been widely recognized.Ital homeostasis depends on the balance of NAD+ synthesis and breakdown,and therapeutic approaches designed to target the NAD+ pathway are expected to be used in treating IBD.This article reviews the research progress of NAD+ metabolism in treating IBD and provides directions for applying NAD+-related therapies in the treatment of IBD.
