Research Progress of Th9 Cells/IL-9 in Gastrointestinal Cancers
10.3969/j.issn.1008-7125.2023.10.008
- VernacularTitle:Th9细胞/IL-9在消化系统恶性肿瘤中的研究进展
- Author:
Ye GU
1
;
Weichang CHEN
Author Information
1. 苏州大学附属第一医院消化内科(215006)
- Keywords:
Th9 Cells;
Interleukin-9;
Gastrointestinal Cancers;
Immunotherapy
- From:
Chinese Journal of Gastroenterology
2023;28(10):626-630
- CountryChina
- Language:Chinese
-
Abstract:
Recently,Th9 cells have been confirmed to be a subtype of CD4+ helper T lymphocytes co-induced by interleukin(IL)-4 and transforming growth factor(TGF)-β,which is mainly characterized by the secretion of IL-9.Previous studies have shown that Th9 cells play an important role in autoimmune diseases,parasitic infections,and allergic diseases.Further,Th9 cells/IL-9 have been found to be involved in tumor immune responses,especially in solid tumors.Th9 cells/IL-9 exhibit powerful anti-tumor properties.However,the role of Th9 cells/IL-9 in the development of gastrointestinal cancers remains unclear.This article reviewed the mechanism of Th9 cell/IL-9 differentiation,biological characteristics and research progress in gastrointestinal cancer.
