Evaluation Value of Serum DcR3 Combined With COSSH-ACLF Score in Short-term Prognosis of Patients With HBV-ACLF
10.3969/j.issn.1008-7125.2023.02.002
- VernacularTitle:血清DcR3联合COSSH-ACLF评分对HBV-ACLF患者短期预后的评估价值
- Author:
Ying ZHANG
1
;
Hailing XU
;
Yanqiu WANG
Author Information
1. 南通大学附属南通第三医院肝病科(226001)
- Keywords:
Hepatitis B virus;
Acute-on-Chronic Liver Failure;
Decoy Receptor 3;
COSSH-ACLF Score;
Prognosis
- From:
Chinese Journal of Gastroenterology
2023;28(2):70-75
- CountryChina
- Language:Chinese
-
Abstract:
Background:HBV-related acute-on-chronic liver failure(ACLF)has a high mortality rate,early and accurate prediction is helpful for formulating the best treatment options.Aims:To investigate the value of serum decoy receptor 3(DcR3)combined with COSSH-ACLF scoring model in predicting short-term(90-day)prognosis in patients with HBV-ACLF.Methods:A total of 205 patients with HBV-ACLF,50 patients with chronic hepatitis B(CHB)and 50 healthy people(control group)from January 2020 to August 2022 at the Third Affiliated Hospital of Nantong University were enrolled.Serum DcR3 level was detected by ELISA.Patients with HBV-ACLF were divided into improvement group and deterioration group according to the survival status at 90 days after admission.Scores of iMELD,CLIF-C ACLF and COSSH-ACLF were calculated.Multivariate Logistic regression analysis was used to evaluate the risk factors affecting short-term prognosis of patients with HBV-ACLF.ROC curve was used to assess the predictive value of serum DcR3 and COSSH-ACLF score.Results:Serum DcR3 level in HBV-ACLF group was significantly higher than that in CHB group and control group(P<0.05).Serum DcR3,iMELD score,CLIF-C ACLF score and COSSH-ACLF score in HBV-ACLF deterioration group were significantly higher than those in improvement group(P<0.001).Multivariate Logistic regression analysis showed that serum DcR3 and COSSH-ACLF score were independent risk factors affecting short-term prognosis of patients with HBV-ACLF(P<0.001).Pearson correlation analysis showed that serum DcR3 was positively correlated with COSSH-ACLF score(r=0.477,P<0.001).ROC curve results showed that AUC of serum DcR3,COSSH-ACLF score for predicting short-term prognosis of patients with HBV-ACLF were 0.869 and 0.897,respectively.AUC of combined prediction model was 0.939.Conclusions:Serum DcR3 and COSSH-ACLF score have a good value in predicting short-term prognosis of patients with HBV-ACLF,and the combination of serum DcR3 and COSSH-ACLF score has higher predictive value.
