Research Advances of Mitochondrial Regulation in Ferroptosis in Alzheimer's Disease
10.3870/j.issn.1672-0741.23.04.003
- VernacularTitle:线粒体调控在阿尔茨海默病铁死亡中的作用研究进展
- Author:
Weihan MENG
1
;
Yue DU
;
Le ZHU
Author Information
1. 武汉科技大学脑科学先进技术研究院,武汉 430065
- Keywords:
ferroptosis;
mitochondrial regulation;
Alzheimer's disease;
iron homeostasis;
lipid peroxidation;
a-mino acid metabolism
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2023;52(6):878-884
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis,a newly defined programmed cell death,is different from classic apoptosis and necrosis.It is charac-terized by intracellular iron accumulation,severe lipid peroxidation,and typical mitochondrial morphological and functional chan-ges.Mitochondrial cascade reactions inducing oxidative stress and neuronal death are important events during the pathogenesis of Alzheimer's disease(AD).This review mainly summarized research advances of the role and mechanism of intracellular iron metabolism,mitochondrial lipid metabolism and amino acid metabolism abnormalities in neuron ferroptosis during progress of AD.
