Role of ferritinophagy in the pathogenesis of diabetes and its complications:A review of literature

VernacularTitle:铁蛋白自噬在糖尿病及其相关并发症发病机制中的研究进展
Author: Jianmei SHI ¹ ; Xixi WANG ; Xiaojie WEI
Author Information

1. 广西中医药大学基础医学院 (南宁 530299);广西高发传染病中西医结合转化医学重点实验室(南宁 530299)
Keywords: ferritin; ferritinophagy; nuclear receptor coactivator 4; diabetes mellitus
From: The Journal of Practical Medicine 2024;40(3):417-422,427
CountryChina
Language:Chinese
Abstract: Diabetes mellitus(DM)is a common metabolic disease,and its hyperglycemia can induce many complications and even threaten human health and life.Ferritinophagy,currently a research focus,has been proven to be related to the occurrence and development of DM and its complications.Ferritinophagy,which is cell-selective,is mediated by nuclear receptor coactivator 4(NCOA4),which degrades ferritin in autophagosomes and releases excessive iron ions so that irons are overloaded and ROS are accumulated.This process contributes to the upstream ferroptosis.This article reviews the mechanism of ferritinophagy and its pathogenesis in DM and its complications,and further analyzes the effects of regulated ferritinophagy on DM and its complications,pro-viding new insight into the prevention and treatment of DM and its complications.