Research progress on the relationship between m6A methylation modification and acute kidney injury

VernacularTitle:m6A甲基化修饰在急性肾损伤中的研究进展
Author: Lili TANG ¹ ; Xinyu WANG ; Jie ZHANG ; Yue ZHAO ; Xiaoyue LI
Author Information

1. 遵义医科大学第五附属(珠海)医院急诊科、重症医学科(广东珠海 519100 )
Keywords: m6A methylation modification; acute kidney injury; septic acute kidney injury; isch-emia/reperfusion injury
From: The Journal of Practical Medicine 2024;40(2):278-282
CountryChina
Language:Chinese
Abstract: Acute kidney injury(AKI)is a global public health problem with high morbidity,high mortality and costly treatment cost.The pathogenesis of AKI is very complex,and the treatment strategies for AKI are lim-ited,then it is very matter to explore the pathophysiological mechanism and potential therapeutic targets of acute kidney injury.N6-methyladenosine(m6A)is the most abundant and extremely conservative epigenetic modification in eukaryotic,which is a dynamic and reversible process involving in splicing,nuclear export,translation,stabil-ity,and higher structure of RNA,and regulated by three regulatory factors:methyltransferase,demethylase and methylated reading protein.Current studies have found that m6A plays an important regulatory role in AKI and can be a potential therapeutic target for AKI.In this review,we provide a brief description of m6A and summarize the impact of m6A on AKI and possible future study directions for this research.