Value of MR 3D-ASL,DWI combined with MGMT in the differential diagnosis of postoperative recurrence and pseudoprogression of high-grade glioma
10.3969/j.issn.1002-1671.2024.04.003
- VernacularTitle:MR 3D-ASL、DWI联合MGMT在高级别脑胶质瘤术后复发与假性进展鉴别诊断中的价值
- Author:
Liying WANG
1
;
Xianhua XU
Author Information
1. 海南省肿瘤医院医学影像部,海南 海口 570312
- Keywords:
high-grade glioma;
three-dimensional arterial spin labeling;
diffusion weighted imaging;
MGMT;
recurrence;
pseudoprogression
- From:
Journal of Practical Radiology
2024;40(4):528-530
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of brain MR three-dimensional arterial spin labeling(3D-ASL),diffusion weighted imaging(DWI)combined with MGMT gene detection in the differential diagnosis of postoperative recurrence and pseudoprogression of high-grade glioma.Methods A total of 30 patients with high-grade glioma were selected,and all patients were divided into pseudoprogression group and recurrence group according to pathological results.The differences in average relative cerebral blood flow(rCBF)and average relative apparent diffusion coefficient(rADC)were compared between recurrence groups and pseudoprogression groups.Results The rCBF in the enhanced center and edge areas in the recurrence group was significantly higher than those in the pseudoprogression group,and the rADC was significantly lower than that in the pseudoprogression group,and the difference was statistically significant(P<0.05).There were correlations between the postoperative recurrence and pseudoprogression of high-grade glioma and the promoter situation of methylation of MGMT gene.Conclusion Brain MR 3D-ASL,DWI combined with MGMT gene detection has important clinical value in the differential diagnosis of postoperative recurrence and pseudoprogression of high-grade glioma.
