Diagnostic value of energy spectrum CT quantitative parameters combined with serum TSHR-mRNA for papillary thyroid microcarcinoma
10.3969/j.issn.1002-1671.2024.01.007
- VernacularTitle:能谱CT定量参数联合血清TSHR-mRNA对甲状腺微小乳头状癌的诊断价值
- Author:
Weiguo ZHANG
1
;
Jiaping LIU
;
Xiangnan LI
;
Jiyang ZHANG
Author Information
1. 首都医科大学附属北京朝阳医院放射科,北京 100020
- Keywords:
energy spectrum computed tomography;
thyroid stimulating hormone receptor-messenger ribonucleic acid;
papillary thyroid microcarcinoma
- From:
Journal of Practical Radiology
2024;40(1):27-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of energy spectrum CT quantitative parameters combined with serum thy-roid stimulating hormone receptor-messenger ribonucleic acid(TSHR-mRNA)for papillary thyroid microcarcinoma(PTMC).Methods A total of 105 patients with thyroid micronodules confirmed by surgery and pathology were collected,61 of whom were PTMC(PTMC group),and 44 patients with micronodular goiter(MNG)(MNG group).Energy spectrum CT quantitative parameters and serum TSHR-mRNA expression were compared between the two groups.The diagnostic value of energy spectrum CT quantitative parame-ters alone and combined with serum TSHR-mRNA for PTMC was analyzed by receiver operating characteristic(ROC)curve.Results The iodine concentration and slope of energy spectrum CT quantitative parameters between PTMC group and MNG group were signifi-cantly different in plain scan,arterial and venous phases(P＜0.05).The mean serum TSHR-mRNA expression in the PTMC group was higher than that in MNG group(P＜0.05).The area under the curve(AUC)for diagnosing PTMC using quantitative parame-ters of energy spectrum CT combined with serum TSHR-mRNA was 0.913,and the accuracy,sensitivity,and negative predictive value of diagnosing PTMC were significantly higher than those of quantitative parameters of energy spectrum CT or serum TSHR-mRNA(P＜0.05).Conclusion Both energy spectrum CT quantitative parameters and serum TSHR-mRNA can be used to diagnose PTMC alone,and the combination of both is more accurately.
