MRI findings and analysis of diffuse midline glioma with H3 K27 mutation
10.3969/j.issn.1002-1671.2023.12.001
- VernacularTitle:伴H3 K27变异的弥漫性中线胶质瘤MRI表现与分析
- Author:
Yan FENG
1
;
Fan GUO
;
Qi ZHAO
;
Longlong WANG
;
Jinsong ZHANG
Author Information
1. 空军军医大学西京医院放射科,陕西 西安 710032
- Keywords:
diffuse midline glioma;
H3 K27 mutation;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2023;39(12):1913-1916
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate MRI features and pathological basis of diffuse midline glioma(DMG)with H3 K27 mutation and to improve the understanding of the clinical and preoperative diagnosis.Methods The imaging,histopathological,molecular pathological and prognostic data of 17 cases DMG with H3 K27 mutation confirmed by pathology were analyzed retrospectively.Results All regions located in midline areas and showed diffuse growth.There were 7 cases located in thalamus(1 case involved bilateral thalamus),3 cases in brainstem.Two cases involved thalamus and brainstem simultaneously.Two cases involved cervical spinal cord.Two cases involved ventriculus tertius and fourth ventricle.One case located in cerebella.Most lesions showed mixed signals,mainly with long signal on T1WI and long signal on T2WI.And 9 cases showed slightly narrow strip peritumoral edema and 8 cases showed no peritumoral edema.Of all cases,there were 9 cases with non-enhancement intensity,8 cases with diverse enhancement patterns.A total of 15 cases underwent fluid attenuated inversion recovery(FLAIR)scans,5 cases showed the T2/FLAIR imaging mismatching characteristics.Six cases were complicated with small cystic necrosis and 5 cases with intra-tumoral hemorrhage.Conclusion DMG with H3 K27 mutation has specific locations and MRI characteristics,including diverse contrast-enhancement patterns,non-or slightly narrow strip peritumoral edema.However,the definite diagnosis depends on pathological results.
