Effects of Basal LH and Different LH/FSH Ratio Levels on Assisted Reproduc-tive Pregnancy Outcomes in Patients with Polycystic Ovary Syndrome
- VernacularTitle:基础黄体生成素和不同LH/FSH比值水平对PCOS患者辅助生殖妊娠结局的影响
- Author:
Zi YE
1
;
Jing WANG
;
Jiayin LIU
Author Information
1. 南京医科大学第一附属医院生殖医学科,江苏 南京 210029;南京医科大学附属无锡人民医院妇科 南京医科大学无锡医学中心,江苏 无锡 214000
- Keywords:
Luteinizing hormone;
Follicle stimulating hormone;
Polycystic ovary syndrome;
Assisted reproduc-tion;
Pregnancy outcome
- From:
Journal of Practical Obstetrics and Gynecology
2024;40(3):213-218
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of basal luteinizing hormone(bLH)and different luteinizing hor-mone/follicle stimulating hormone ratio(LH/FSH)on the pregnancy outcome of in vitro fertilization or intracyto-plasmic sperm injection(IVF/ICSI)in patients with polycystic ovary syndrome(PCOS).Methods:From July 2013 to January 2020,424 PCOS patients who underwent flexible gonadotropin-releasing hormone antagonist protocol for ovulation induction in first IVF/ICSI were collected retrospectively from the department of reproductive medi-cine,The First Affiliated Hospital of Nanjing Medical University.The patients were divided into normal bLH(LH≤10 U/L,316 cases)and high bLH(LH>10 U/L,108 cases)group according to different levels of bLH;At the same time,according to the different levels of LH/FSH ratio,they were divided into low ratio(LH/FSH≤1,227 cases)group,median ratio(10.05).②Compared with patients in different LH/FSH ratio groups,the high ratio group had higher AMH and antral follicle count(AFC)than the other two groups,and the differences were statistically significant(P<0.05).In terms of ovulation induction,the high ratio group had lower numbers of retrieved eggs,transferred embryos,and endometrial thickness on HCG day compared to the other two groups,with statistically significant differences(P<0.05).There was no statistically significant difference in pregnancy outcome indicators among the three groups of patients(P>0.05).③Binary Logistic regression analy-sis showed no significant correlation between live birth rate and bLH,LH/FSH ratio(P>0.05),but the live birth rate was related to the number of embryos transferred(P<0.05).Conclusions:Elevated bLH level and LH/FSH ratio may affect the outcomes of ovulation induction in women with PCOS(such as the number of oocytes re-trieved and endometrial thickness on HCG injection day),but there is no significant correlation with live birth rate of assisted reproduction.
