Research progress on susceptibility genes in children with tic disorder
10.3760/cma.j.cn101070-20230714-00584
- VernacularTitle:儿童抽动障碍的遗传易感基因研究进展
- Author:
Huimin CHEN
1
;
Dan SUN
;
Zhisheng LIU
Author Information
1. 华中科技大学同济医学院附属武汉儿童医院神经内科，武汉 430016
- Keywords:
Susceptibility gene;
Neurotransmitter;
Tic disorder;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2024;39(4):314-317
- CountryChina
- Language:Chinese
-
Abstract:
Tic disorder (TD) is a neurodevelopmental disorder that starts in childhood with tics as its primary clinical manifestation.It is a group of movement disorders with unknown causes.At present, the main pathogenic genes of TD have not been identified.In this paper, TD neurotransmitter-associated susceptibility genes ( DRD2, DRD4, SLC6A4, HDC, ADRA2A), related susceptibility gene variations ( ASH1L, CELSR3, PNKD, NRXN1, CNTN6), and other susceptibility genes ( FLT3, SLITRK1) were reviewed to provide references for the precision treatment based on gene variations.
