Clinicopathological features of Langerhans cell histiocytosis involving thyroid gland
10.3969/j.issn.1672-8467.2024.01.013
- VernacularTitle:累及甲状腺的朗格汉斯细胞组织细胞增生症的临床病理分析
- Author:
Zhe JIN
1
;
Qian WU
;
Lan LIN
;
Feng TANG
Author Information
1. 复旦大学附属眼耳鼻喉科医院病理科 上海 200031
- Keywords:
Langerhans cell histiocytosis(LCH);
thyroid disease;
pathology
- From:
Fudan University Journal of Medical Sciences
2024;51(1):89-95
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the clinical and pathological characteristics of Langerhans cell histiocytosis(LCH)involving thyroid gland.Methods We reviewed 5 cases of histologically confirmed LCH with thyroid gland involvement in Huashan Hospital,Fudan University from Jun 2017 to Nov 2022 and analyzed their clinicopathological features.Results There were 1 male and 4 females aged from 29 to 54 years,with a median age of 31 years.Ultrasound showed hypoechoic nodules of thyroid.Morphologically,there were a large number of Langerhans cells,which contained abundant eosinophilic cytoplasm.The nucleus was oval,or had deeply grooved nuclei,which was like coffee beans.The nucleolus was not obvious,accompanied by a variable number of lymphocytes and eosinophils infiltration.The lesional cells were positive for CD1α,S100,Langerin,and Ki67 proliferation index was more than 15%,of which the highest was 70%.The tested 4 cases were all BRAF V600E and MAP2K1 gene mutation negative.Conclusion Cases limited to the thyroid were exceedingly rare.Most cases occurred in patients with multifocal disease.The clinical manifestations were painless enlargement of the thyroid gland.Surgical resection was a common treatment.Pathological manifestations included a large number of Langerhans cells and eosinophils diffused with the destruction of normal thyroid follicular structures.There was a characteristic of low mutation rates in BRAF V600E and MAP2K1 genes.
