Analysis of HPV infection and genotype distribution among 1 658 male reproductive health outpatients
10.3969/j.issn.1672-8467.2024.01.010
- VernacularTitle:1658例生殖健康门诊男性HPV感染情况及基因型分布特征分析
- Author:
Nazhakaiti ABUDUKELIMU
1
;
Jian-Hui LI
;
Tian-Cheng ZHANG
;
Xin WANG
;
Zhi-Ming XU
;
Qian-Xi ZHU
Author Information
1. 上海市生物医药技术研究院,上海市疾病与健康基因组学重点实验室,国家卫健委计划生育药具重点实验室 上海 200237;复旦大学公共卫生学院 上海 200032
- Keywords:
human papillomavirus;
genotype;
vaccine;
male;
infection
- From:
Fudan University Journal of Medical Sciences
2024;51(1):69-75
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the human papillomavirus(HPV)infection and genotype distribution characteristics among male reproductive health outpatients,and to compare the differences among different age groups of outpatients.Methods A total of 1 658 males,visited in the Affiliated Hospital of Shanghai Institute of Planned Parenthood Research from 2018 to 2022,were selected and 23 HPV genotypes were detected by PCR-reverse dot hybridization.Results Among the 1 658 subjects,the overall HPV infection rate was 22.50%.Single infection accounted for 66.76%,which was the main infection type.HPV infection among different age groups were statistically significant(P<0.001),with HPV infection of 16.83%,22.87%,34.63%,and 29.35%for 18-30,31-40,41-50,and≥51 years,respectively.The top 5 high risk HPV genotypes were HPV52(3.56%),HPV16(3.26%),HPV39(2.41%),HPV51(2.17%),HPV58(2.17%),and the top 1 low risk HPV genotype was HPV81(2.90%).The proportions of infected individuals in this study that could be completely covered by bivalent,quadrivalent,and nine-valent HPV vaccines were 7.77%,12.33%,and 26.27%,respectively.Conclusion The predominant infection type among male reproductive health outpatients was single infection type.HPV 52,16,39,51 and 58 were the most common high risk genotypes,while HPV 81 was the most common low risk genotype.Individuals aged 41-50 years had the highest HPV infection rate.
