Clinical outcomes of living related kidney transplant recipients with hyperuricemia
10.3760/cma.j.cn.115807-20230809-00053
- VernacularTitle:亲属间活体捐献肾移植术后高尿酸血症患者的临床分析
- Author:
Xiaowei JIA
1
;
Xiaoyan SONG
;
Peng LI
;
Liang WANG
;
Jianmin YU
;
Ling DENG
;
Liping CHEN
Author Information
1. 中国人民解放军总医院第八医学中心干部诊疗科，北京 100091
- Keywords:
Hyperuricemia;
Living related kidney transplantations;
Delayed graft function;
Survival rate of the transplanted kidney
- From:
Chinese Journal of Endocrine Surgery
2023;17(6):656-659
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical outcomes of living related kidney transplantation (LRKT) recipients with hyperuricemia.Methods:A retrospective analysis was conducted on the medical records of 212 cases of LRKTs performed between Jan. 2015 and Dec. 2021. All cases involved children who received a kidney transplant donated by their parents. Based on the average blood uric acid levels (>420 μmol/L) between 1 to 12 months postoperatively, the patients were divided into two groups: the hyperuricemia group (HUA, n=43) and the non-hyperuricemia group (non-HUA, n=169) . Demographic information, the incidence of adverse events within one year after the operation, serum creatinine (Scr) levels, and the survival rate of the transplanted kidney at 1, 3, and 5 years after the operation were compared between the groups. Results:The non-HUA group had a significantly shorter preoperative dialysis duration compared to the HUA group (median 350 days vs 484 days) . The incidence of delayed graft function and acute rejection within 1 year postoperatively was significantly higher in the HUA group compared to the non-HUA group (14.0% vs 4.7% and 11.6% vs 2.4%) . At 1, 3, and 5 years after surgery, the serum creatinine levels in the HUA group were significantly higher than those in the Non HUA group, which were (131.1±31.2) vs (116.3±32.1) mmol, (133.6±34.7) vs (119.9±31.9) mmol/L, and (137.3±32.4) vs (115.4±30.3) mmol/L. The survival rate of kidney transplantation was slightly lower in the HUA group compared to the non-HUA group, but the difference was not statistically significant.Conclusions:Hyperuricemia in kidney transplant recipients who received a donor kidney from their parents is associated with increased incidences of delayed graft function and acute rejection, as well as compromised graft kidney function.
