Triple negative breast cancer:a study based on histological and immunohistochemical classification
10.13315/j.cnki.cjcep.2024.03.009
- VernacularTitle:三阴型乳腺癌基于组织学、免疫组化分型的分析
- Author:
Jing LIAN
1
;
Li HUANG
;
Peng BU
;
Hong SU
;
Yanfeng XI
Author Information
1. 山西省肿瘤医院/中国医学科学院肿瘤医院山西医院/山西医科大学附属肿瘤医院病理科,太原 030013
- Keywords:
breast neoplasm;
triple-negative breast cancer;
subtyping;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2024;40(3):268-273
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To evaluate the classification criteria of triple negative breast cancer(TNBC)based on histomorphol-ogy and immunohistochemistry(IHC),and to provide theoreti-cal basis for the classification and treatment of TNBCs.Methods TNBC subtyping was performed according to the histomorphologi-cal characteristics and the expression of immune markers AR,CD8 and FOXC1,and the clinicopathological features and prog-nostic differences were compared.Results Among 93 cases of TNBC,there were 23 cases(24.7％)of luminal androgen re-ceptor subtypes,24 cases(25.8％)of immunomodulatory type,39 cases(42.0％)of basal immunosuppressive type,and 7 ca-ses(7.5％)of mesenchymal type.There were significant differ-ences in the clinicopathological features of subtypes,including pT stage(P=0.030),histological grade(P＜0.001),intersti-tial lymphocyte infiltration pattern(P＜0.001),expression of PD-L1(P＜0.001),and HER2-low(P=0.024).There was no significant difference in disease-free survival among the sub-types(P＞0.05).Univariate survival analysis showed there was significant difference in disease-free survival among the subtypes at pT1 stage(P=0.011),and other clinicopathological features were not independent prognostic factors.Conclusion The clini-copathological characteristics of TNBC subtypes are different,which are expected to be an alternative choice for complex gene expression profile analysis and to provide theoretical basis for subtypic therapy and targeted therapy.
