Analysis of clinical and pathological characteristics of drug-induced live injury based on hepatotoxicity injury patterns
10.13315/j.cnki.cjcep.2024.02.011
- VernacularTitle:基于生物化学异常模式的药物性肝损伤临床病理特征分析
- Author:
Honghai XU
1
;
Shiwei ZHU
;
Hui ZHANG
;
Yufeng GAO
;
Hua WANG
Author Information
1. 安徽医科大学第一附属医院病理科,合肥 230022
- Keywords:
drug-induced live injury;
hepatotoxicity injury pat-terns;
pathological features;
clinical manifestations
- From:
Chinese Journal of Clinical and Experimental Pathology
2024;40(2):172-178
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the clinical and pathologi-cal features and the relationships between pathological features and drugs of patients with drug-induced liver injury(DILI)based on the hepatotoxicity injury patterns.Methods The clin-ical data,laboratory indicators,drugs,and liver biopsy of 50 cases of DILI were collected,the expression of CK19 was detec-ted by immunohistochemistry EnVision two-step method,and the reticular scaffold of liver tissue was displayed by Reticular fiber staining.Results Among the 50 patients with DILI,there were 29 cases of hepatocellular DILI,11 cases of cholestatic DILI,and 10 cases of mixed DILI,respectively,with the hepatocellu-lar DILI accounting for the highest proportion(58％).7 catego-ries of drugs induced DILI,with herbal ranking first(52％).Different types of drugs could cause different types of DILI,with herbal induced 17 cases hepatocellular DILI(58.62％)and an-ti-infectious and anticancer drugs induced all 3 cases cholestatic DILI(27.27％).Different types of DILI displayed various pathological characteristics.Hepatocellular congestion,feathery degeneration,and small bile duct thrombosis primarily occur in cholestasis and mixed DILI,while bridging necrosis,sub-large and large necrosis were mainly seen in hepatocellular DILI.Conclusion Based on hepatotoxicity injury patterns,DILI ex-hibits a variety of clinical and pathological characteristics,and there is some relationship between pathological characteristics and drugs.Liver puncture pathological biopsy plays an important role in improving the diagnosis and treatment of DILI.
