Association of tumor budding in preoperative biopsies with clinicopathological characteristics and prognosis of colorectal cancer
10.13315/j.cnki.cjcep.2023.12.017
- VernacularTitle:术前活检标本中肿瘤出芽与结直肠癌临床病理学特征及预后的相关性
- Author:
Lulu YANG
1
;
Wenbin ZHOU
;
Jinsong WANG
;
Wenbin HUANG
;
Yuan FANG
Author Information
1. 南京医科大学附属南京医院(南京市第一医院)病理科,南京 210006
- Keywords:
colorectal neoplasms;
tumor budding;
intratumoral budding;
biopsies;
prognosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2023;39(12):1497-1502
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the association of tumor budding in preoperative biopsies with the clinicopathological characteristics of colorectal cancer(CRC),and its effects on the prognosis.Methods A total of 144 preoperative biopsies and corresponding radical resection specimens of colorectal ade-nocarcinoma were collected.Tumor budding was evaluated by HE staining and EnVision immunohistochemical staining,to an-alyze the association of tumor budding with the clinicopathologi-cal characteristics and prognosis in biopsies.Results The de-tection rate of intra-tumoral budding(ITB)in biopsy specimens was 39.6%(57/144),and peritumoural budding(PTB)in surgical specimens was 64.6%(93/144);ITB was significantly correlated with PTB(r =0.510,P<0.05).The proportion of patients with lymph node metastasis,pTNM stage,differentiated degree,vascular invasion and nerve recidivism in the tumor bud-ding group of biopsies was significantly higher than that in no tumor budding group(P<0.05).Kaplan-Meier survival analy-sis showed that ITB significantly affected the overall survival and progression free survival of CRC(P<0.05).Conclusion The presence of ITB in biopsies tissue may be an important indicator of invasive behavior and poor prognosis in CRC.
