Research progress on the mechanism of autophagy's role in perioperative neurocognitive disorders
- VernacularTitle:自噬在围术期神经认知障碍中作用的研究进展
- Author:
Xiaojia ZHANG
1
;
Chun'ai WANG
Author Information
- Keywords: Perioperative neurocognitive disorders; Anaesthesia; Autophagy
- From: The Journal of Clinical Anesthesiology 2024;40(2):204-208
- CountryChina
- Language:Chinese
- Abstract: Perioperative neurocognitive disorders commonly manifest as impaired memory and con-fusion in patients,prolonged hospitalisation,poor prognosis,and increased mortality.Autophagy is closely related to the onset of perioperative neurocognitive disorder.Drugs,aging and inflammation affect autophagy levels by regulating signaling pathways such as mTOR and FOXO1,which are involved in the pathogenesis of perioperative neurocognitive disorder.Autophagy plays an important role in improving postoperative cogni-tive dysfunction and learning memory by modulating neuroinflammation,α-synuclein,and τ protein metabo-lism.This article reviews the main pathways regulating autophagy and the role of autophagy in the occurrence and development of perioperative neurocognitive disorders,in order to seek new targets and ideas for the pathogenesis of perioperative neurocognitive disorders.
