Effects of Different Virulence Types of Helicobacter Pylori on Gastric Micro-environment
10.12259/j.issn.2095-610X.S20240221
- VernacularTitle:不同毒力型的幽门螺旋杆菌对胃内微环境的影响
- Author:
Xiaoqing ZHAO
1
;
Jiaxin XIAO
;
Yong LIN
;
Jianfeng ZHANG
;
Wenhui WANG
;
Wenjie ZHANG
Author Information
1. 广东省中医院珠海医院脾胃病科,广东 珠海 519000
- Keywords:
Helicobacter pylori;
Pepsinogen;
IL-6;
IL-8;
Gastrin 17;
PG Ⅰ;
PG Ⅱ
- From:
Journal of Kunming Medical University
2024;45(2):148-152
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of different virulence types of Helicobacter pylori on pepsin and inflammatory factors.Methods 110 patients admitted from December 2021 to March 2023 were collected and divided into HP positive group(n=79)and HP negative group(n=31)according to 13 carbon breath test results.The HP positive group was divided into type Ⅰ group(n=52),type Ⅱ group(n=11)and undetermined group(n=16)according to the Helicobacter pylori antibody typing.The HP negative group was selected and divided into blank control group(n=12).Gastric juice pH value,sodion(Na+),potassium(K+),chloridion(Cl-),IL-6,IL-8,gastrin 17(G-17),pepsinogen Ⅰ(PG Ⅰ)and pepsinogen Ⅱ(PG Ⅱ)were detected in all patients.Results Th-ere was no difference in pH,Na+,Cl-,K+ between Hp positive group and Hp negative group(P>0.05).The content of Cl-in HP-positive group was lower than that in HP-negative group(P<0.05).The levels of IL-6,IL-8,G-17,PG Ⅰ and PG Ⅱ in HP-positive group were significantly higher than those in HP-negative group(P<0.05).There was no significant difference in pH,Na+ and K+ between type Ⅰ group and type Ⅱ group,undetermined group and blank control group(P>0.05).The content of Cl-in type Ⅰ group and undetermined group was lower than that in blank control group(P<0.05).The levels of IL-6,IL-8 and PG Ⅰ in type I group were higher than those in type Ⅱ group,undetermined group and blank control group(P<0.05).There was a significant difference in PG Ⅱ between the blank control group and the other groups(P<0.05).There was no difference in G-17 content between type Ⅰ group and undetermined group(P>0.05).The level of G-17 in type I group was higher than that in type Ⅱ group and blank control group(P<0.05).Conclusion Type I Hp infection may cause gastric mucosal injury by increasing the expression of IL-6,IL-8 and G-17,and then lead to abnormal digestive function.
