Systematic evaluation of prehospital external hemostatic dressings
10.7644/j.issn.1674-9960.2023.12.008
- VernacularTitle:院前外用止血敷料的系统性评价
- Author:
Rui SUN
1
;
Fei SHU
;
Kai SONG
;
Yuanlin ZHANG
;
Dan HAN
;
Lei REN
;
Lixin SHU
Author Information
1. 海军军医大学药学系军队药材保障论证中心,上海 200433;武警甘肃省总队医院,兰州 730050
- Keywords:
prehospital;
hemostatic dressings;
hemostasis rate;
chitosan;
zeolites;
evaluation index
- From:
Military Medical Sciences
2023;47(12):928-933
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effectiveness,safety and operability of different types of pre-hospital topical hemostatic dressings given the limited clinical evidence of pre-hospital topical hemostatic dressings so as to provide reference for the subsequent establishment of a comprehensive index system.Methods A systematic review method was used to sift through and summarize the evaluation indexes of zeolite,kaolin and chitosan.Results Fifteen studies were included,only one of which was randomized controlled trial(RCT)study,and the rest were descriptive studies,involving military and civilian subjects.All the three types of hemostatic dressings in the included studies had good haemostatic effects,but the amount of data was too limited to compare the haemostatic effects between different types.Except for zeolite wounds that were likely to be burned by exothermic heat,the other types caused few adverse reactions but with unclear operability.There was no data on stability and economy in the selected literature.Conclusion Considering the ideal hemostatic agent and the standard requirements of Chinese expert consensus,it is recommended that the indicators in follow-up studies include efficacy,safety,operability,stability and economy,and that preclinical animal studies be included to supplement related indicators.
