Research progress on cholesterol metabolism in the regulation of colorectal cancer
10.11855/j.issn.0577-7402.0364.2022.0831
- VernacularTitle:胆固醇代谢在结直肠癌调控中的作用研究进展
- Author:
Chi YANG
1
;
Chang-Jiang LUO
Author Information
1. 兰州大学第二医院普通外科,甘肃兰州 730030
- Keywords:
cholesterol metabolism;
colorectal cancer;
molecular mechanism;
targeted therapy
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(2):236-244
- CountryChina
- Language:Chinese
-
Abstract:
Cholesterol metabolism is a hot topic in exploration of cancer treatment in recent years,and its complex mechanism of action potentially lays a molecular foundation related to lipid-cancer.However,most studies focus only on cholesterol as a product to understand and analyze the progress of cancer,ignoring the phased effects of related derivatives,regulatory proteins and immune cells in its metabolic process,so whether to find targets to regulate colorectal cancer(CRC)from the cholesterol metabolic pathway has become a research focus.This paper reviews the molecular mechanism and the role of signaling pathways in metabolic reprogramming of CRC starting from the abnormal intracellular cholesterol metabolic pathway in order to provide new ideas for the targeted cholesterol therapy of CRC.
